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Ro 41-0960
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ro 41-0960图片
CAS NO:125628-97-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Ro 41-0960 是一种选择性儿茶酚-O-甲基转移酶 (COMT) 抑制剂。
Cas No.125628-97-9
Canonical SMILESOC1=C(O)C=C(C(C2=CC=CC=C2F)=O)C=C1[N+]([O-])=O
分子式C13H8FNO5
分子量277.2
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ro 41-0960 is a catechol-O-methyltransferase (COMT) inhibitor.1 It prevents dopaminergic neuron loss induced by L-DOPA in primary rat rostral mesencephalic tegmentum cultures (EC50 = 0.1 μM). Ro 41-0960 (30 mg/kg) potentiates L-DOPA and carbidopa-induced reversal of reserpine-induced akinesias in rats and reserpine-induced catalepsy and hypothermia in mice.2 It reduces striatal 3-methyl-DOPA levels and increases striatal dopamine and 3,4-dihydroxyphenylacetic acid levels in rats. Ro 41-0960 (150 mg/kg) also reduces fibroid volume in the Eker rat model of uterine fibroids.3