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GS-441524
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GS-441524图片
CAS NO:1191237-69-0
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
GS-441524 是 Remdesivir 的主要代谢物，在对抗 Covid-19 方面优于 Remdesivir，在感染冠状病毒的原代人肺和猫细胞的基于细胞的模型中显示出相当的功效。
Cas No.1191237-69-0
化学名2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-D-altrononitrile
Canonical SMILESNC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@H](O)[C@H](O)[C@@H](CO)O3
分子式C12H13N5O4
分子量291.3
溶解度10mg/mL in DMSO or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GS-441524 is an antiviral nucleoside analog and the active metabolite of remdesivir. [1] GS-441524 is active against Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome CoV (SARS-CoV) in infected primary human airway epithelial (HAE) cells (EC50s = 0.86 and 0.18 μM, respectively). It is cytoprotective against hepatitis C virus (HCV), yellow fever virus (YFV), dengue virus type 2 (DENV-2), influenza A, and parainfluenza 3 in cell-based assays (EC50s = 4.1, 11, 9.46, 27.9, and 1.71 μM, respectively).[2]

Reference:
[1]. Agostini, M.L., Andres, E.L., Sims, A.C., et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. mBio 9(2), e00221-00218 (2018).
[2]. Cho, A., Saunders, O.L., Butler, T., et al. Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides. Bioorg. Med. Chem. 22(8), 2705-2707 (2012).