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OUL35
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OUL35图片
CAS NO:6336-34-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
OUL35 (NSC39047) 是一种有效的选择性 ARTD10 (PARP-10) 抑制剂,IC50 为 329 nM。
Cas No.6336-34-1
别名NSC39047
Canonical SMILESNC(C1=CC=C(OC2=CC=C(C(N)=O)C=C2)C=C1)=O
分子式C14H12N2O3
分子量256.3
溶解度DMF: 5 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.20 mg/ml
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

OUL35 is an inhibitor of poly(ADP-ribose) polymerase 10 (PARP10; IC50 = 329 nM).1 It is selective for PARP10 over a panel of 15 PARP enzymes, including PARP4, PARP14, and PARP16 (IC50s = 22.6, 23.4, and 4.17 μM, respectively). OUL35 (10 μM) reverses inhibition of HeLa cell proliferation induced by PARP10 overexpression. It sensitizes HeLa cells to hydroxyurea , increasing hydroxyurea-induced inhibition of cell proliferation when used at a concentration of 5 μM.

|1. Venkannagari, H., Verheugd, P., Koivunen, J., et al. Small-molecule chemical probe rescues cells from mono-ADP-ribosyltransferase ARTD10/PARP10-induced apoptosis and sensitizes cancer cells to DNA damage. Cell Chem. Bio. 23(10), 1251-1260 (2016).