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Benzolamide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Benzolamide图片
CAS NO:3368-13-6
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Benzolamide (CL11366) 是一种有效的碳酸酐酶 (CA) 抑制剂，抑制hCA I，hCA II，EcoCAγ 和 VchCAγ 的 Ki 值分别为15 nM，9 nM，94 nM 和 78 nM。Benzolamide 还抑制 CAS3，Ki 值为 54 nM。Benzolamide 可用于青光眼和癫痫的研究。
Cas No.3368-13-6
别名CL11366
分子式C8H8N4O4S3
分子量320.37
溶解度DMSO : 250 mg/mL (780.35 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Benzolamide (CL11366) is a potent carbonic anhydrase (CA) inhibitor, with Kis of 15 nM, 9 nM, 94 nM and 78 nM for hCA I, hCA II, EcoCAγ and VchCAγ, respectively. Benzolamide also inhibits CAS3, with a Ki of 54 nM. Benzolamide can be used for the research of glaucoma and seizures[1][2][3].

Benzolamide inhibits hCA I, hCA II, EcoCAγ and VchCAγ, with Kis of 15 nM, 9 nM, 94 nM and 78 nM, respectively[1].Benzolamide shows selectivity for CAS3 (Ki=54 nM) over CAS1 (Ki=2115 nM) and CAS2 (Ki=410 nM)[2].

Benzolamide (90 µmol/kg; i.p.) decreases brain pH and suppresses electrographic post-asphyxia seizures in rats[3].

[1]. Prete SD, et, al. Escherichia coli γ-carbonic anhydrase: characterisation and effects of simple aromatic/heterocyclic sulphonamide inhibitors. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1545-1554.
[2]. Vullo D, et, al. Sulfonamide Inhibition Studies of the β-Class Carbonic Anhydrase CAS3 from the Filamentous Ascomycete Sordaria macrospora. Molecules. 2020 Feb 25;25(5):1036.
[3]. Pospelov AS, et, al. Carbonic anhydrase inhibitors suppress seizures in a rat model of birth asphyxia. Epilepsia. 2021 Jun 27.