CAS NO: | 62595-11-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Cas No. | 62595-11-3 |
别名 | L-色氨酸-D5,Tryptophan-d5; Tryptophane-d5 |
Canonical SMILES | OC([C@@H](N)CC1=C([2H])NC2=C([2H])C([2H])=C([2H])C([2H])=C12)=O |
分子式 | C11H7D5N2O2 |
分子量 | 209.3 |
溶解度 | PBS (pH 7.2): 1 mg/ml |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | L-Tryptophan-d5is intended for use as an internal standard for the quantification of L-tryptophan by GC- or LC-MS. L-Tryptophan is an essential amino acid.1It serves as a substrate for tryptophan hydroxylase (TPH), indoleamine-2,3-dioxygenase (IDO), and tryptophan-2,3-dioxygenase (TDO) for the biosynthesis of serotonin and kynurenine .2L-Tryptophan is also metabolized by enteric bacteria expressing tryptophanase into indole, pyruvate, and ammonia.3It increases 5-HT, 5-hydroxy-L-tryptophan (5-HTP), and 5-hydroxy indole-3-acetic acid (5-HIAA) levels in the diencephalon of rats when administered at a dose of 300 mg/kg.4L-Tryptophan decreases immobility time in the forced swim test in rats when administered at doses of 4 and 20 mg/kg per day for eight weeks.5 1.Richard, D.M., Dawes, M.A., Mathias, C.W., et al.L-Tryptophan: Basic metabolic functions, behavioral research and therapeutic indicationInt. J. Tryptophan Res.245-60(2009) 2.O’Mahony, S.M., Clarke, G., Borre, Y.E., et al.Serotonin, tryptophan metabolism and the brain-gut-microbiome axisBehav. Brain Res.27732-48(2015) 3.Wikoff, W.R., Anfora, A.T., Liu, J., et al.Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolitesProc. Natl. Acad. Sci. USA106(10)3698-3703(2009) 4.Esteban, S., Nicolaus, C., Garmundi, A., et al.Effect of orally administered L-tryptophan on serotonin, melatonin, and the innate immune response in the ratMol. Cell Biochem.267(1-2)39-46(2004) 5.Ouakki, S., El Mrabet, F.Z., El Hessni, A., et al.Conversion of L-tryptophan into melatonin is the possible action pathway involved in the effect of L-tryptophan on antidepressant-related behavior in female rats: Analysis of the influence of treatment durationJ. Behav. Brain Sci.3(4)362-372(2013) |