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Pitavastatin lactone-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pitavastatin lactone-d4图片
包装与价格:
包装价格(元)
500 µg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of pitavastatin lactone
Canonical SMILESFC1=C([2H])C([2H])=C(C2=C(/C=C/[C@@H]3C[C@@H](O)CC(O3)=O)C(C4CC4)=NC5=C2C=CC=C5)C([2H])=C1[2H]
分子式C25H18D4FNO3
分子量407.5
溶解度Ethanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pitavastatin lactone-d4is intended for use as an internal standard for the quantification of pitavastatin lactone by GC- or LC-MS. Pitavastatin lactone is a major phase 2 metabolite of the HMG-CoA reductase inhibitor pitavastatin .1,2Pitavastatin lactone is formed when pitavastatin undergoes glucuronidation by the UDP-glucuronysyltransferase (UGT) isoforms UGT1A1, UGT1A3, or UGT2B7 to form pitavastatin glucuronide, which then undergoes non-enzymatic conversion to pitavastatin lactone. It can be retroconverted to pitavastatinviahydrolysis.

1.Fujino, H., Yamada, I., Shimada, S., et al.Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: Human UDP-glucuronosyltransferase enzymes involved in lactonizationXenobiotica33(1)27-41(2003) 2.Aoki, T., Nishimura, H., Nakagawa, S., et al.Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductaseArzneimittelforschung47(8)904-909(1997)