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SH-42
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
SH-42图片
CAS NO:2143952-36-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
SH-42 是一种有效的选择性人 Δ24-脱氢胆固醇还原酶 (DHCR24) 抑制剂，IC50 为 42 nM。
Cas No.2143952-36-5
Canonical SMILESC[C@@]12[C@]3([H])C([C@@]4([H])[C@](CC3)([C@]([C@@H](COC=O)C)([H])CC4)C)=CC[C@@]1([H])C[C@H](CC2)OC(C)=O
分子式C25H38O4
分子量402.6
溶解度Chloroform: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SH-42 is an inhibitor of ?24-dehydrocholesterol reductase (DHCR24; IC50= 4.2 nM).1It increases serum levels of desmosterol , the immediate precursor of cholesterol in the Bloch pathway, in mice when administered at a dose of 0.5 mg/animal per day. SH-42 increases levels of arachidonic acid and its metabolite prostaglandin E2, as well as docosahexaenoic acid and its metabolites 19,20-EpDPA and 19,20-DiHDPA, in the peritoneal lavage fluid in a mouse model of peritonitis induced by zymosan A .2

1.MÜller, C., Hemmers, S., Bartl, N., et al.New chemotype of selective and potent inhibitors of human delta 24-dehydrocholesterol reductaseEur. J. Med. Chem.140305-320(2017) 2.KÖrner, A., Zhou, E., MÜller, C., et al.Inhibition of δ24-dehydrocholesterol reductase activates pro-resolving lipid mediator biosynthesis and inflammation resolutionProc. Natl. Acad. Sci. USA116(41)20623-20634(2019)