CAS NO: | 172747-50-1 |
包装: | 1mg |
市场价: | 1750元 |
Cas No. | 172747-50-1 |
化学名 | 4-[4-ethyl-2-(4-methoxyphenyl)-1H-imidazol-5-yl]-pyridine |
Canonical SMILES | CCC1=C(C2=CC=NC=C2)N=C(C3=CC=C(OC)C=C3)N1 |
分子式 | C17H17N3O |
分子量 | 279.3 |
溶解度 | Soluble in methanol;Soluble in DMSO |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition. SB 202190 and SB 203580 are potent and selective inhibitors of the MAP kinases p38α and p38β [1][2][3]. Mitogen-activated protein kinases (MAPKs) are ser/thr-specific protein kinases that regulate gene expression, proliferation, differentiation, cell survival and apoptosis. Three most widely characterized MAPK subfamilies are ERK1/2, JNK and p38MAPK, of which JNK and p38MAPK are identified as a stress-activated protein kinase (SAPK) that primarily mediates inflammatory response and promotes cell death [3]. SB 202474 is a structural analog of SB 202190 and SB 203580 that is used as a negative control in researches of p38 inhibition. In 3T3-L1 adipocytes and L6 myotubes, SB203580 but not SB202474 prevented insulin-stimulated glucose transport [2]. Pretreatment with microinjection into the bilateral rostral ventrolateral medulla (RVLM) of SB203580 (2 nmol) significantly exacerbated the depressor effect and blunted the augmented power density of the LF component of SAP signals during the pro-life phase. SB203580 also significantly shortened the pro-life phase to 60 min. SB202474 (2 nmol) was ineffective against the phasic cardiovascular responses in the aCSF-control group or Mev-experimental group [3]. References: |