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SR 3576
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SR 3576图片
包装与价格:
包装价格(元)
50mg电议
10mg电议

产品介绍
SR 3576 是一种高效的选择性 JNK3 抑制剂,IC50 为 7 nM。

Cell lines

Human ovarian cancer cisplatin-resistant SKOV3/DDP cells

Preparation method

The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 ℃ for 10 minutes and/or shake it in the ultrasonic bath for a while. Stock solution can be stored below -20℃ for several months.

Reacting condition

24 h, 2 μM

Applications

SR 3576 is a specific inhibitor of JNK3. Inhibition of JNK3 by SR 3576 exacerbates oxidative stress and suppresses autophagic flux, resulting in an increase of apoptosis induced by S1 in human ovarian cancer SKOV3/DDP cells.

产品描述

SR-3576 is a cell-permeable, potent and selective JNK3 (c-Jun N-terminal kinase 3) inhibitor.

SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.