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CHPG Sodium salt
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CHPG Sodium salt图片
CAS NO:1303993-73-8
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
CHPG 钠盐是一种选择性 mGluR5 激动剂，可通过 BV2 小胶质细胞中的 TSG-6/NF-κB 通路减弱 SO2 诱导的氧化应激和炎症。
Cas No.1303993-73-8
化学名sodium (R)-2-amino-2-(2-chloro-5-hydroxyphenyl)acetate
Canonical SMILESClC(C=C1)=C(C=C1O)[C@H](C([O-])=O)N.[Na+]
分子式C8H7ClNNaO3
分子量223.59
溶解度Soluble in DMSO
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells[1]. CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways.[2].

CHPG sodium salt (10-500 μM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO2 derivatives treatment[1]. CHPG sodium salt (0.5 mM; 30 mins ) protects BV2 cells against SO2-induced apoptosis[1]. CHPG sodium salt (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels[1].

CHPG sodium salt (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume[2].

References:
[1]. Qiu JL, et al. The selective mGluR5 agonist CHPG attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells. Neurochem Int. 2015 Jun-Jul;85-86:46-52.
[2]. Chen T, et al. The selective mGluR5 agonist CHPG protects against traumatic brain injury in vitro and in vivo via ERK and Akt pathway. Int J Mol Med. 2012 Apr;29(4):630-6.