您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > CMPD-1
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
CMPD-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CMPD-1图片
CAS NO:41179-33-3
包装与价格：
包装价格(元)
10mg电议
50mg电议

产品介绍
CMPD-1 是一种选择性和非 ATP 竞争性 p38 MAPK 介导的 MK2 磷酸化抑制剂，表观 Ki (Kiapp) 为 330 nM。
Cas No.41179-33-3
化学名4-(2'-fluoro-[1,1'-biphenyl]-4-yl)-N-(4-hydroxyphenyl)butanamide
Canonical SMILESFC1=CC=CC=C1C2=CC=C(C=C2)CCCC(NC(C=C3)=CC=C3O)=O
分子式C22H20FNO2
分子量349.4
溶解度<34.94mg/ml in DMSO;<34.94mg/ml in ethanol
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CMPD1 is a selective and non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor with apparent Ki (Kiapp) of 330 nM[1][2].

CMPD1 does not inhibit p38 MAPK-mediated phosphorylation of other two substrates, MBP and ATF2[1].CMPD1 induced mitotic arrest and apoptosis in U87 cells[1].CMPD1 inhibits tubulin polymerisation in glioblastoma cells[3].

References:
[1]. Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.
[2]. Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.
[3]. Phoa AF, et al. Pharmacology of novel small-molecule tubulin inhibitors in glioblastoma cells with enhanced EGFR signalling. Biochem Pharmacol. 2015 Dec 15;98(4):587-601.