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AZ Dyrk1B 33
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZ Dyrk1B 33图片
CAS NO:1679330-37-0
包装:10mg
市场价:4351元

产品介绍
AZ Dyrk1B 33 是\u200b\u200b一种有效的选择性 Dyrk1B 激酶抑制剂,IC50 为 7 nM。
Cas No.1679330-37-0
Canonical SMILESCC1=NC=CC(C2=CN(CC3=CC=CC=C3)C4=CN=CC=C42)=N1
分子式C19H16N4
分子量300.36
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Potent and selective ATP-competitive Dyrk1B kinase inhibitor (IC50 = 7 nM); displays distinct cellular effects when compared to DYRK1B knockdown through siRNA. Demonstrates cellular in vitro activity (IC50 = 194 nM). Exhibits better selectivity than AZ 191 ; displays no off-target effects against a panel of 124 kinases tested (no kinase was inhibited above 50% at 1 μM).

Kettle et al (2015) Discovery and optimization of a novel series of Dyrk1B kinase inhibitors to explore a MEK resistance hypothesis. J.Med.Chem. 58 2834 PMID:25738750