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SRI-011381
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SRI-011381图片
CAS NO:1629138-41-5
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
SRI-011381 是一种口服活性 TGF-β 信号激动剂,具有神经保护作用。
Cas No.1629138-41-5
Canonical SMILESO=C(NC1CCCCC1)N(CC2CCNCC2)CC3=CC=CC=C3
分子式C20H31N3O
分子量329.5
溶解度DMF: 15mg/mL,DMSO: 20mg/mL,Ethanol: 25mg/mL,Ethanol:PBS (pH 7.2) (1:4): 0.2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SRI-011381 is an activator of TGF-β signaling.1 It reduces increases in cell death and the number of dystrophic neurites induced by amyloid-β (1-42) in primary mouse embryonic forebrain neurons when used at a concentration of 3 μM. SRI-011381 (2 and 5 μM) increases phagocytosis of Aβ42 by greater than 20% in J774A.1 and THP-1 macrophages. It increases contextual fear conditioning freezing time and spontaneous alternations in the Y-maze, indicating prevention of memory deficits, in the APP751Lon,Swe transgenic mouse model of Alzheimer's disease when administered at a dose of 10 mg/kg for 10 weeks.