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Vorolanib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vorolanib图片
CAS NO:1013920-15-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Vorolanib (CM082; X-82) 是一种具有口服活性的 VEGFR/PDGFR 抑制剂。Vorolanib 最大限度地降低了毒性,破坏肿瘤的血管生成和肿瘤细胞增殖,并诱导肿瘤细胞死亡。
Cas No.1013920-15-4
别名CM082; X-82
Canonical SMILESO=C1/C(C2=CC(F)=CC=C2N1)=C/C(NC(C)=C3C(N[C@@H]4CN(C(N(C)C)=O)CC4)=O)=C3C
分子式C23H26FN5O3
分子量439.48
溶解度DMSO: 27 mg/mL (61.44 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Vorolanib (CM082; X-82) is an orally active, multikinase VEGFR/PDGFR inhibitor. Vorolanib minimizes toxicity, disrupts tumor angiogenesis and tumor cell proliferation, and induces of tumor cell death[1].

[1]. Bendell JC, et al. Phase I, First-in-Human, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Vorolanib in Patients with Advanced Solid Tumors. Oncologist. 2019 Apr;24(4):455-e121.