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XY028-133
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
XY028-133图片
CAS NO:2229974-73-4
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
XY028-133 (example 14) 是基于PROTAC 的 CDK4/6 的降解剂。
Cas No.2229974-73-4
分子式C53H67N11O7S
分子量1002.23
溶解度DMSO : 50 mg/mL (49.89 mM; Need ultrasonic)
储存条件Store at -20°C, sealed storage, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

XY028-133 (example 14) is a PROTAC-based CDK4/6 degrader with anti-tumor activity[1].

XY028-133 (1 and 3 μM, 24 h) significantly decreases CDK4/6, Cyclin A, PLK1 and pRb protein levels in A375 cells[1].

[1]. JIN, Jian, et al. COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER. Patent. US2017/065027.