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LCAHA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LCAHA图片
CAS NO:117094-40-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
LCAHA (LCA hydroxyamide) 是一种脱泛素酶 USP2a 抑制剂,在 Ub-AMC 分析和 Di-Ub 分析中, IC50 分别为 9.7 μM 和 3.7 μM。LCAHA 通过抑制去泛素酶 USP2a 破坏细胞周期蛋白 D1 稳定性并诱导 G0/G1 期阻滞。
Cas No.117094-40-3
别名LCA hydroxyamide
分子式C24H41NO3
分子量391.59
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9.7 μM and 3.7μM in Ub-AMC Assay and Di-Ub Assay, respectively. LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a[1].

LCAHA inhibits HCT116wt and HCT116 p53-/- colon cancer cells viability with GI50s of 0.87±0.09 and 0.96±0.29μM, respectively, and the LD50s of 27.8±3.9 and 26.5±0.1μM, respectively[1].

[1]. Katarzyna Magiera, et al. Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G 0/G1 Arrest by Inhibiting Deubiquitinase USP2a. Cell Chem Biol. 2017 Apr 20;24(4):458-470.e18.