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XY028-140
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
XY028-140图片
CAS NO:2229974-83-6
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
XY028-140 是一种选择性 CDK4/CDK6 降解剂。XY028-140 抑制癌细胞中的 CDK4/6 表达和 CDK4/6 活性。
Cas No.2229974-83-6
分子式C39H40N10O7
分子量760.8
溶解度DMSO : 5.56 mg/mL (7.31 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

XY028-140 is a selective CDK4/CDK6 degrader. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1].

A375 melanoma and T47D breast cancer cells are treated with 0.3 or 1 µμ XY028-140 for 24 hours. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity[1]. T47D breast cancer cells are treated with 0.03, 0.1, 0.3, 1, or 3 µμ XY028-140 for 11 days. XY028-140 inhibits cancer cell proliferation in breast cancer cells[1].

[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.