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2′-Deoxy-2′-fluoroadenosine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2′-Deoxy-2′-fluoroadenosine图片
CAS NO:64183-27-3
包装:100mg
市场价:450元

产品介绍
2′-Deoxy-2′-fluoroadenosine可用于合成可与RNA杂交的2'-脱氧-2'-氟修饰的寡核苷酸。2′-Deoxy-2′-fluoroadenosine能被大肠杆菌嘌呤核苷磷酸化酶(PNP)有效地裂解成毒性物2-氟腺嘌呤(FAde)。2′-Deoxy-2′-fluoroadenosine对表达大肠杆菌PNP的肿瘤表现出良好的体内活性。
Cas No.64183-27-3
别名2'-氟-2'-脱氧腺苷
Canonical SMILESOC[C@@H]1[C@H]([C@@H](F)[C@H](N2C=NC3=C(N=CN=C32)N)O1)O
分子式C10H12FN5O3
分子量269.23
储存条件4℃, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2′-Deoxy-2′-fluoroadenosine can be used for the synthesis of 2′-Deoxy-2′-fluoro-modified oligonucleotides hybridized with RNA. 2′-Deoxy-2′-fluoroadenosine can be cleaved efficiently by E. coli purine nucleoside phosphorylase (PNP) to the toxic agent 2-fluoroadenine (FAde). 2′-Deoxy-2′-fluoroadenosine shows excellent in vivo activity against tumors expressing E. coli PNP[1].

[1]. A E Hassan, et al. A convenient synthesis of 2'-deoxy-2-fluoroadenosine; a potential prodrug for suicide gene therapy. Nucleosides Nucleotides Nucleic Acids. 2000 Mar;19(3):559-65.