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Loureirin A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Loureirin A图片
CAS NO:119425-89-7
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议

产品介绍
LoureirinA是从龙血树中分离到的黄酮类物质,能够降低Akt的磷酸化,具有抗血小板聚集的作用。
Cas No.119425-89-7
别名龙血素 A
Canonical SMILESO=C(C1=CC=C(O)C=C1)CCC2=CC=C(OC)C=C2OC
分子式C17H18O4
分子量286.32
溶解度DMSO : ≥ 86.6 mg/mL (302.46 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity.

Loureirin A (50 μM, 100 μM) inhibits collagen-induced platelet ATP secretion and thrombin-stimulated P-selectin expression in a dose-dependent manner. Loureirin A also significantly impairs platelet spreading on immobilized fibrinogen. Loureirin A almost completely eliminates collagen-induced Akt phosphorylation at Ser473 at the dose of 100 μM, and has an additive inhibitory effect with the phosphoinositide 3-kinase (PI3K) inhibitor Ly294002 on collage-induced Akt phosphorylation in platelets at 50 μM[1].

[1]. Hao HZ, et al. Antiplatelet activity of loureirin A by attenuating Akt phosphorylation: In vitro studies. Eur J Pharmacol. 2015 Jan 5;746:63-9.