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FNC-TP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
FNC-TP图片
CAS NO:2457357-99-0
包装:1mg
市场价:8820元

产品介绍
FNC-TP 是 FNC 的细胞内活性形式。FNC 是一种有效的核苷逆转录酶抑制剂 (NRTI)，对 HIV、HBV 和 HCV 具有抗病毒活性。
Cas No.2457357-99-0
分子式C9H14FN6O13P3
分子量526.16
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FNC-TP is the intracellular active form of FNC. FNC is a potent nucleoside reverse transcriptase inhibitor (NRTI), with antiviral activity on HIV, HBV and HCV[1].

FNC (0.1-10 nM; 24-240 h) is found mainly to accumulate in these HIV-1 target cells, and the retention of FNC-TP is 2-4 times higher than in other types of cells[1].

FNC (1-6 mg/kg; a single p.o.) could enter rhesus macaque PBMCs and form the active nucleoside triphosphate FNC-TP[1].

[1]. Sun L, et, al. Mechanistic Insight into Antiretroviral Potency of 2’-Deoxy-2’-β-fluoro-4’-azidocytidine (FNC) with a Long-Lasting Effect on HIV-1 Prevention. J Med Chem. 2020 Aug 13;63(15):8554-8566.