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CYM 5478
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CYM 5478图片
CAS NO:870762-83-7
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
CYM 5478 是一种有效且高度选择性的 S1P2 激动剂，在 TGFα 脱落试验中 EC50 为 119 nM。
Cas No.870762-83-7
Canonical SMILESFC(F)(F)C(C=C1)=CN(CC(C2=C(C)N(CC3=CC=CC=C3)C(C)=C2)=O)C1=O
分子式C21H19F3N2O2
分子量388.4
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CYM 5478 is a sphingosine-1-phosphate receptor 2 (S1P2) agonist (EC50 = 0.78 μM in a reporter assay).1 It is selective for S1P2 over S1P1 and S1P3-5 in a TGFα-shedding assay (EC50s = 119, 1,690, 1,950, >10,000, and >10,000 nM, respectively). CYM 5478 (0.1-10 μM) reduces serum starvation-induced decreases in C6 rat glioma cell viability. It also reduces accumulation of reactive oxygen species (ROS) and apoptosis induced by cisplatin in C6 cells when used at a concentration of 10 μM.

|1. Herr, D.R., Reolo, M.J., Peh, Y.X., et al. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: Implications for otoprotective therapy. Sci. Rep. 6, 24541 (2016).