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DM4-SPDP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DM4-SPDP图片
CAS NO:2245698-48-8
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
DM4-SPDP 是由连接桥 SPDP 和 毒性分子 DM4 连接而成的，可用来制备抗体偶联药物。DM4 是抑制细胞分裂的抗微管蛋剂。SPDP 是一种短链交联剂，可通过 NHS-酯和吡啶基二硫醇反应性基团与半胱氨酸巯基形成可裂解的 (可还原的) 二硫键，实现胺与巯基的结合。
Cas No.2245698-48-8
Canonical SMILESCOC1=CC(C/C(C)=C/C=C/[C@@H](OC)[C@]2(O)NC(OC([C@@H](C)[C@H]3[C@](O3)(C)[C@@H](OC([C@H](C)N(C(CCC(C)(C)SSCCC(ON4C(CCC4=O)=O)=O)=O)C)=O)CC5=O)C2)=O)=CC(N5C)=C1Cl
分子式C45H61ClN4O14S2
分子量981.57
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DM4-SPDP is a drug-linker conjugate composed of a potent antitubulin agent DM4 and a linker SMCC to make antibody drug conjugate[1]. SPDP is a short-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteine sulfhydryls[2][3].

[1]. Tang R, et al. P-gp activity is a critical resistance factor against AVE9633 and DM4 cytotoxicity in leukaemia cell lines, but not a major mechanism of chemoresistance in cells from acute myeloid leukaemia patients. BMC Cancer. 2009 Jun 23;9:199. [2]. Lobedanz S et al. A periplasmic coiled-coil interface underlying TolC recruitment and the assembly of bacterial drug effluxpumps. Proc Natl Acad Sci U S A, 2007 Mar 13, 104(11):4612-7. [3]. Karumuthil-Melethil S et al. Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1diabetes. J Immunol 2010 Jun 15, 184(12):6695-708.