CAS NO: | 38819-10-2 |
包装 | 价格(元) |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
Cas No. | 38819-10-2 |
别名 | 9-Β-D-糖呋喃鸟嘌呤 |
Canonical SMILES | O[C@H]1[C@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O[C@@H]1CO |
分子式 | C10H13N5O5 |
分子量 | 283.2 |
溶解度 | DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: Partially soluble,PBS (pH 7.2): 0.3 mg/ml |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Ara-G is an analog of the nucleoside guanosine and an active metabolite of nelarabine .1,2 Ara-G accumulates in T lymphoblasts and malignant T-lymphoid cells, where it is phosphorylated to produce ara-GTP and incorporated into the DNA.3,1 Ara-G inhibits DNA replication by 92% after 30 minutes when used at a concentration of 50 μM in CEM cells, which are used as a model for human T lymphoblasts.1 It also halts the cell cycle at the sub-G1 phase and induces apoptosis in CEM cells.3 Syngeneic bone marrow containing 6C3HED tumor cells treated with ara-G (100 mM) ex vivo prior to transplantation increases survival of lethally irradiated mice and induces reconstitution of lymphoid, myeloid, and erythroid cell linages.4 References |