Isovaleryl-L-carnitine (chloride) 是 L-亮氨酸分解代谢的产物，是人中性粒细胞 Ca2+- 依赖性蛋白酶（钙蛋白酶）的有效激活剂。
| Cas No. | 139144-12-0 |
| 别名 | L-异戊酰基肉碱 |
| Canonical SMILES | OC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O.[Cl-] |
| 分子式 | C12H24NO4•Cl |
| 分子量 | 281.8 |
| 溶解度 | DMF: 15 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Isovaleryl-L-carnitine is a naturally occurring acylcarnitine that is formed via metabolic conversion of L-leucine. It increases survival and decreases apoptosis in hepatocyte growth factor-deprived murine C2.8 hepatocytes when used at a concentration of 1 mM. Isovaleryl-L-carnitine inhibits amino acid deprivation-induced proteolysis and autophagy in isolated perfused rat liver when used at concentrations of 77 and 100 μM, respectively. Increased levels of isovaleryl carnitine are associated with isovaleryl-CoA dehydrogenase deficiency (isovaleric acidemia). |
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