Ac-PAL-AMC 是 20S 蛋白酶体 LMP2/β1i 活性特异性的荧光底物。
| Cas No. | 1431362-79-6 |
| Canonical SMILES | CC(C1=CC=C(NC([C@H](CC(C)C)NC([C@H](C)NC([C@@H]2CCCN2C(C)=O)=O)=O)=O)C=C1O3)=CC3=O |
| 分子式 | C26H34N4O6 |
| 分子量 | 498.6 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ac-PAL-AMC is a fluorogenic substrate for the β1i/LMP2 subunit of the 20S immunoproteasome. Upon cleavage, 7-amino-4-methylcoumarin (AMC) is released and its fluorescence can be used to quantify the activity of the β1i/LMP2 subunit of the 20S immunoproteasome. Ac-PAL-AMC is selective for the immunoproteasome over the constitutive proteasome. AMC displays excitation/emission maxima of 351/430 nm, respectively. |
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