Indomethacin-D4 (Indometacin-D4) 是一种氘标记的吲哚美辛。
| Cas No. | 87377-08-0 |
| 别名 | 吲哚美辛-D4; Indometacin-d4 |
| Canonical SMILES | CC1=C(CC(O)=O)C(C=C(OC)C=C2)=C2N1C(C3=C([2H])C([2H])=C(Cl)C([2H])=C3[2H])=O |
| 分子式 | C19H12ClD4NO4 |
| 分子量 | 361.8 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 18 mg/ml,Ethanol: 7 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Indomethacin-d4 is intended for use as an internal standard for the quantification of indomethacin by GC- or LC-MS. Indomethacin is a non-selective COX inhibitor (IC50s = 1.67 and 24.6 µM for human COX-1 and COX-2, respectively). It reduces filter paper-disc induced growth of granulation tissue, a marker of inflammation, in chick chorioallantoic membranes. Indomethacin reduces ocular inflammation induced by bovine serum in rabbits. It also reduces paw edema in a rat model of carrageenan-induced inflammation. |
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