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DC661
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DC661图片
CAS NO:1872387-43-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
DC661 是一种有效的棕榈酰蛋白硫酯酶 1 (PPT1) 抑制剂,可抑制自噬,并作为抗溶酶体剂。抗癌活性。
Cas No.1872387-43-3
Canonical SMILESCN(CCCCCCNC1=CC=NC2=CC(Cl)=CC=C12)CCCCCCNC3=CC=NC4=CC(Cl)=CC=C34
分子式C31H39Cl2N5
分子量552.58
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor, inhibits autophagy, and acts as an anti-lysosomal agent. Anti-cancer activity[1].

DC661 (0.1 and 10 μM) accumulates autophagic vesicles in melanoma cells[1].

Reference:

[1]. Rebecca VW, et al. PPT1 Promotes Tumor Growth and Is the Molecular Target of Chloroquine Derivatives in Cancer. ancer Discov. 2019 Feb;9(2):220-229.