1,2,3,4,5,6-六溴环己烷是一种溴代烃，是一种有效的 JAK2 酪氨酸激酶自磷酸化抑制剂。
| Cas No. | 1837-91-8 |
| 别名 | 1,2,3,4,5,6-六溴化环己烷 |
| 化学名 | 1,2,3,4,5,6-hexabromocyclohexane |
| Canonical SMILES | C1(C(C(C(C(C1Br)Br)Br)Br)Br)Br |
| 分子式 | C6H6Br6 |
| 分子量 | 557.54 |
| 溶解度 | ≥ 8.2mg/mL in DMSO with gentle warming |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. A 16-hour treatment with 1 μM of compound reduces JAK2 tyrosine autophosphorylation levels to ~ 50% while 50 μM elimates nearly all JAK2 activity. Non-cytotoxic at 100 μM. |
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