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Daphnetin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Daphnetin图片
CAS NO:486-35-1
包装:20mg
市场价:693元

产品介绍
Daphnetin (7,8-dihydroxycoumarin) 是一种可在 Daphne 属植物中发现的香豆素衍生物，是一种有效的口服活性蛋白激酶抑制剂，对 EGFR、PKA 和 PKC 的 IC50 分别为 7.67 μM、9.33 μM 和 25.01 μM体外，分别。
Cas No.486-35-1
别名瑞香素; 7,8-Dihydroxycoumarin
化学名7,8-dihydroxychromen-2-one
Canonical SMILESC1=CC(=C(C2=C1C=CC(=O)O2)O)O
分子式C9H6O4
分子量178.14
溶解度Ethanol: 5 mg/ml
储存条件Store at 2-8℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative isolated from plants of the Genus Daphne, is a protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively[1][2]. Daphnetin (7,8-dihydroxycoumarin) is a secondary metabolite of plants used in folk medicine to counter inflammatory and allergic diseases, also has been clinically used in the treatment of coagulation disorders, rheumatoid arthritis with anti-malarian and anti-pyretic properties[3].

References:
[1]. Yang EB, et al. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260(3):682-5.
[2]. Lv H, et al. Daphnetin-mediated Nrf2 antioxidant signaling pathways ameliorate tert-butyl hydroperoxide (t-BHP)-induced mitochondrial dysfunction and cell death. Free Radic Biol Med. 2017 May;106:38-52.
[3]. Jiménez-Orozco FA, et al. Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity. Eur J Pharmacol. 2011 Oct 1;668(1-2):35-41.