CAS NO: | 23180-57-6 |
包装: | 20mg |
市场价: | 672元 |
Cas No. | 23180-57-6 |
别名 | 芍药苷; Peoniflorin |
化学名 | ((2S,2aR,2a1S,3aR,4R,5aR)-4-hydroxy-2-methyl-2a-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-1,5-dioxa-2,4-methanocyclobuta[cd]pentalen-2a1-yl)methyl benzoate |
Canonical SMILES | O=C(C1=C([H])C([H])=C([H])C([H])=C1[H])OC([H])([H])[C@@]2([C@@]3([H])C4([H])[H])[C@]4([C@@](C5([H])[H])(C([H])([H])[H])O[C@]2([H])O[C@@]35O[H])O[C@]([C@]([C@@]6([H])O[H])([H])O[H])([H])O[C@@](C([H])([H])O[H])([H])[C@@]6([H])O[H] |
分子式 | C23H28O11 |
分子量 | 480.47 |
溶解度 | DMF: 30 mg/mL,DMSO: 30 mg/mL,Ethanol: 30 mg/mL,PBS (pH 7.2): 10 mg/mL |
储存条件 | Store at -20℃ |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3]. References: |