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RMC-0331
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RMC-0331图片
CAS NO:2488788-52-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
RMC-0331 (RM-023) 是一种高效、选择性和口服生物利用度 SOS1 抑制剂。RMC-0331 是一种体内工具化合物,通过破坏 RAS-SOS1 相互作用阻断 RAS 激活。
Cas No.2488788-52-7
别名RM-023
分子式C22H25ClF3N5O3
分子量499.91
溶解度DMSO : 125 mg/mL (250.05 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RMC-0331 (RM-023) is a potent, selective and orally bioavailable SOS1 inhibitor. RMC-0331 is an in vivo tool compound that blocks RAS activation via disruption of the RAS-SOS1 interaction[1].

RMC-0331 has an IC50 of 71 nM measuring by the rate of GDP/GTP exchange in vitro[1].

RMC-0331 (100-250 mg/kg; p.o.; qd; immunocompetent mice) shows single agent anti-tumor activity in SHP2-mutant models[1].

[1]. Andreas Buckl, et al. Discovery of a Potent, Selective and Orally Bioavailable SOS1 Inhibitor, RMC-0331 (RM-023), an in vivo Tool Compound that Blocks RAS Activation via Disruption of the RAS-SOS1 Interaction.