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Mocravimod hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Mocravimod hydrochloride图片
CAS NO:509088-69-1
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Mocravimod hydrochloride (KRP-203) 是一种免疫抑制剂,有效的,具有口服活性的 S1PR1 (1-磷酸鞘氨醇受体 1 型) 激动剂。
Cas No.509088-69-1
别名2-氨基-2-[2-[2-氯-4-[[3-(苄氧基)苯基]硫]苯基]乙基]-1,3-丙二醇盐酸盐,KRP-203
分子式C24H27Cl2NO3S
分子量480.45
溶解度DMSO : 100 mg/mL (208.14 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Mocravimod hydrochloride (KRP-203), an immunosuppressant, is a potent and orally active S1PR1 (sphingosine 1-phosphate receptor type 1) agonist[1][2].

Mocravimod hydrochloride (KRP-203) ameliorates atherosclerosis in LDL-R-/- Mice[1]. Mocravimod hydrochloride (KRP-203) (orally; 0.1 and 1 mg/kg/day; for 100 days) prolongs graft survival and attenuates chronic rejection in mHC-disparate rat heart allografts[2].

[1]. PotÌ F, et al. KRP-203, sphingosine 1-phosphate receptor type 1 agonist, ameliorates atherosclerosis in LDL-R-/- mice. Arterioscler Thromb Vasc Biol. 2013 Jul;33(7):1505-12.
[2]. Shimizu H, et al. KRP-203, a novel synthetic immunosuppressant, prolongs graft survival and attenuates chronicrejection in rat skin and heart allografts. Circulation. 2005 Jan 18;111(2):222-9. Epub 2005 Jan 10.