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JHU 37152
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JHU 37152图片
CAS NO:2369979-67-7
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
JHU 37152 是一种有效的脑渗透性 DREADD 激动剂,在 HEK-293 细胞中对 hM3Dq 和 hM4Di DREADD 的 EC50 分别为 5 nM 和 0.5 nM。
Cas No.2369979-67-7
Canonical SMILESCCN1CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC(F)=C24)CC1
分子式C19H20ClFN4
分子量358.85
溶解度DMSO|35.88|100|ethanol|35.88|100|
储存条件Store at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

High affinity and highly potent activator of hM3Dq and hM4Di DREADDs (Ki values are 1.8 nM and 8.7 nM for hM3Dq and hM4Di in vitro, respectively; EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in vitro, respectively). Selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. Inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons. Brain penetrant in mice, rats and non-human primates.