CAS NO: | 960226-55-5 |
包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
Cas No. | 960226-55-5 |
别名 | 他达拉非-D3,IC-351-d3 |
Canonical SMILES | O=C1N(C([2H])([2H])[2H])CC(N2[C@H](C3=CC=C(OCO4)C4=C3)C5=C(C6=CC=CC=C6N5)C[C@@]21[H])=O |
分子式 | C22H16D3N3O4 |
分子量 | 392.4 |
溶解度 | DMSO: Soluble,Methanol: Soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Tadalafil-d3is intended for use as an internal standard for the quantification of tadalafil by GC- or LC-MS. Tadalafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50= 1.2 nM).1It is selective for PDE5 over PDE1-4 and 7-10 (IC50s = 9.2-280 μM), however, it does also inhibit PDE11 (IC50= 11 nM).In vivo, tadalafil (10 mg/kg) decreases production of the proinflammatory cytokines TNF-α, IL-1β, and IL-6 and improves renal function in a rat model of ischemia/reperfusion injury.2It also reduces development of tobacco smoke-induced emphysema and pulmonary hypertension in mice.3Formulations containing tadalafil have been used to treat erectile dysfunction, pulmonary arterial hypertension, and lower urinary tract dysfunction. 1.Card, G.L., England, B.P., Suzuki, Y., et al.Structural basis for the activity of drugs that inhibit phosphodiesterasesStructure12(12)2233-2247(2004) 2.Medeiros, V.F., Azevedo, Í.M., Carvalho, M.D., et al.The renoprotective effect of oral tadalafil pretreatment on ischemia/reperfusion injury in ratsActa. Cir. Bras.32(2)90-97(2017) 3.Seimetz, M., Parajuli, N., Pichl, A., et al.Cigarette smoke-induced emphysema and pulmonary hypertension can be prevented by phosphodiesterase 4 and 5 inhibition in micePLoS One10(6)e0129327(2015) |