| CAS NO: | 497063-94-2 |
| 包装: | 1mg |
| 市场价: | 3251元 |
| Cas No. | 497063-94-2 |
| 别名 | 沙美特罗-D3 |
| Canonical SMILES | OC([2H])([2H])C1=CC(C(O)([2H])CNCCCCCCOCCCCC2=CC=CC=C2)=CC=C1O |
| 分子式 | C25H34D3NO4 |
| 分子量 | 418.6 |
| 溶解度 | DMSO: 100 mM,Ethanol: 50 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Salmeterol-d3is intended for use as an internal standard for the quantification of salmeterol by GC- or LC-MS. Salmeterol is a long-acting β2-adrenergic receptor agonist (β2-AR; EC50s = 0.79, 63.1, and 9.4 nM for β2-, β1-, and β3-ARs, respectively).1It inhibits electrically-stimulated contraction of isolated guinea pig trachea strips (EC50= 2.51 nM) and histamine-induced bronchoconstriction in guinea pigsviaaerosol administration of doses ranging from 0.12 to 12 mM.2Salmeterol binds to an exosite domain of β2-adrenergic receptors, producing a slow onset of action and prolonged activation.3Formulations containing salmeterol have been used in the treatment of asthma, including exercise-induced asthma, and chronic obstructive pulmonary disease. 1.Procopiou, P.A., Barrett, V.J., Ford, A.J., et al.The discovery of long-acting saligenin β2 adrenergic receptor agonists incorporating a urea groupBioorg. Med. Chem.19(20)6026-6032(2011) 2.Ball, D.I., Brittain, R.T., Coleman, R.A., et al.Salmeterol, a novel, long-acting β2-adrenoceptor agonist: Characterization of pharmacological activity in vitro and in vivoBr. J. Pharmacol.104(3)665-671(1991) 3.Isin, B., Estiu, G., Wiest, O., et al.Identifying ligand binding conformations of the β2-adrenergic receptor by using its agonists as computational probesPLoS One7(12)e50186(2012) |
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