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20(S)-Hydroxycholesterol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
20(S)-Hydroxycholesterol图片
CAS NO:516-72-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) 是平滑化癌蛋白 (Smo) 的变构激活剂，可在使用 NIH3T3 细胞的基因转录报告基因分析中激活hedgehog (Hh) 信号通路，EC50 为 3 μM。
Cas No.516-72-3
别名20Α-羟基胆固醇,20α-hydroxy Cholesterol
化学名(3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
Canonical SMILESO[C@](CCCC(C)C)(C)[C@@H]1[C@](CC2)(C)[C@@H](CC1)[C@H]3[C@H]2[C@](CC[C@@H]4O)(C)C(C4)=CC3
分子式C27H46O2
分子量402.65
溶解度≤20mg/ml in ethanol; 0.1mg/ml in DMSO; 2mg/ml in dimethyl formamide
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells[1][2].

References:
[1]. Nachtergaele S, et al. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nat Chem Biol. 2012 Jan 8;8(2):211-20.
[2]. Nedelcu D, et al, Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling. Nat Chem Biol. 2013 Sep;9(9):557-64.