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Streptimidone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Streptimidone图片
CAS NO:738-72-7
包装与价格:
包装价格(元)
500μg电议
5mg电议

产品介绍
A bacterial metabolite with diverse biological activities
Cas No.738-72-7
别名链米酮
Canonical SMILESO=C(CC(C[C@@H](O)CC([C@@H](C)/C=C(C)/C=C)=O)C1)NC1=O
分子式C16H23NO4
分子量293.4
溶解度Soluble in DMSO
储存条件Store at -20℃, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Streptimidone is a bacterial metabolite that has been found in Streptomyces and has diverse biological activities.1,2,3 It inhibits protein synthesis in a cell-free assay when used at a concentration of 50 μg/ml.2 Streptimidone (20 and 100 μg/disc) inhibits the growth of S. cerevisiae and the plant pathogenic fungus C. miyabeanus in a disc diffusion assay.1 It reduces tumor growth in H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma rat xenograft models when administered at doses of 12.5 and 25 mg/kg per day.3

|1. Kondo, H., Oritani, T., and Kiyota, H. Synthesis and antifungal activity of the four stereoisomers of streptimidone, a glutarimide antibiotic from Streptomyces rimosus forma paromomycinus. Eur. J. Org. Chem. (20), 3459-3462 (2000).|2. Bennett, L.L., Ward, V.L., and Brockman, R.W. Inhibition of protein synthesis in vitro by cycloheximide and related glutarimide antibiotics. Biochim. Biophys. Acta. 103(3), 478-485 (1965).|3. Teller, M.N. Antibiotics in experimental cancer chemotherapy. Trans. N. Y. Acad. Sc. 24, 158-166 (1961).