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GKK1032B
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GKK1032B图片
CAS NO:358375-11-8
包装:1mg
市场价:3402元

产品介绍
GKK1032B 是一种生物碱化合物，可以在内生真菌青霉中找到。 GKK1032B可通过caspase通路激活诱导人骨肉瘤MG63细胞凋亡。
Cas No.358375-11-8
Canonical SMILESC[C@@H]1C[C@H](C)[C@]2([H])[C@@]([C@@](C(C)=C[C@@](C=C)(C)[C@]3([H])C4=O)([H])[C@]3([H])[C@]2([H])OC5=CC=C(C[C@@]6([H])[C@@]4([H])C(NC6=O)=O)C=C5)(C)C1
分子式C32H39NO4
分子量501.7
溶解度Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GKK1032B is a fungal metabolite originally isolated from Penicillium sp. GKK1032 that has antiproliferative and antibacterial activities.1,2 GKK1032B inhibits the growth of HeLa S3 cervical and MCF-7 breast cancer cells (IC50s = 17.7 and 14.71 μM, respectively) and Vero cells (IC50 = 29.55 μM). It also inhibits the growth of B. subtilis (MIC = 20.8 μg/ml) and M. tuberculosis (MIC = 48.35 μM).

|1. Li, X.-W., Ear, A., and Nay, B. Hirsutellones and beyond: Figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds. Nat. Prod. Rep. 30(6), 765-782 (2013).|2. Rukachaisirikul, V., Satpradit, S., Klaiklay, S., et al. Polyketide anthraquinone, diphenyl ether, and xanthone derivatives from the soil fungus Penicillium sp. PSU-RSPG99. Tetrahedron 70(34), 5148-5152 (2014).