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Thymohydroquinone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Thymohydroquinone图片
CAS NO:2217-60-9
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
 
Cas No.2217-60-9
别名瑞香[草]氫醌
Canonical SMILESCC(C)C1=C(O)C=C(C)C(O)=C1
分子式C10H14O2
分子量166.2
溶解度DMF: 1 mg/mL,DMSO: 1 mg/mL,Ethanol: 2 mg/mL,Ethanol:PBS (pH 7.2) (1:9): 0.1mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Thymohydroquinone is a quinone that has been found in N. sativa seeds and has diverse biological activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl free radicals in a cell-free assay (IC50 = 2.4 μg/ml) and has a Trolox equivalent value of 2.6 in an oxygen radical absorbance capacity (ORAC) assay when used at concentrations ranging from 1.6 to 6.4 μg/ml.1 Thymohydroquinone inhibits growth of A2780, OVCAR-8, and CIS-A2780 ovarian cancer cells (IC50s = 3.1, 8.9, and 9.8 μM, respectively), as well as immortalized human ovarian epithelial cells (IC50 = 14 μM).2 It is also active against P. falciparum in vitro (IC50 = 15.9 μM).

References
1. Tesarova, H., Svobodova, B., Kokoska, L., et al. Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds. Nat. Prod. Commun. 6(2), 213-216 (2011).
2. Johnson-Ajinwo, O.R., Ullah, I., Mbye, H., et al. The synthesis and evaluation of thymoquinone analogues as anti-ovarian cancer and antimalarial agents. Bioorg. Med. Chem. Lett. 28(7), 1219-1222 (2018).