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CAY10736
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CAY10736图片
CAS NO:2251753-61-2
包装与价格：
包装价格(元)
500μg电议
1mg电议

产品介绍
 
Cas No.2251753-61-2
Canonical SMILESC=C1C(C(C)(C)[C@@](CC[C@]2(C)[C@]3([H])CC=C4[C@@]2(C)CC[C@]5(C(NCCNC(NC6=CC=C(OC)C=C6)=S)=O)[C@@]4([H])CC(C)(C)CC5)([H])[C@]3(C)C1)=O
分子式C41H59N3O3S
分子量674
溶解度Chloroform: soluble,Ethanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CAY10736 is an anticancer compound.1 It inhibits proliferation in a panel of melanoma and breast, pancreatic, and lung cancer cell lines (IC50s = 0.827-9.89 μM). CAY10736 inhibits migration and epithelial-to-mesenchymal transition (EMT) of A375 and B16/F10 melanoma cells in vitro in a concentration-dependent manner. It reduces the viability of spheroid A375 and B16/F10 cells (IC50s = 2.4 and 1.59 μM, respectively) and increases the production of reactive oxygen species (ROS) in these cells in a concentration-dependent manner. CAY10736 (5 mg/kg) reduces tumor growth in B16/F10 melanoma and Lewis lung carcinoma mouse models and an A375 mouse xenograft model.

References
1. Liu, X., Li, B., Zhang, Z., et al. Synthesis and discovery novel anti-cancer stem cells compounds derived from the natural triterpenoic acids. J. Med. Chem. 61(23), 10814-10833 (2018).