您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > N1-Acetylspermine(hydrochloride)
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
N1-Acetylspermine(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
N1-Acetylspermine(hydrochloride)图片
CAS NO:77928-70-2
包装与价格：
包装价格(元)
25mg电议
50mg电议

产品介绍

N1-Acetylspermine is a monoacetylated derivative of spermine, an endogenous polyamine synthesized from spermidine, that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine.

Cas No.77928-70-2
别名N1-乙酰精胺三盐酸盐
化学名N-[3-[[4-[(3-aminopropyl)amino]butyl]amino]propyl]-acetamide, trihydrochloride
Canonical SMILESCC(NCCCNCCCCNCCCN)=O.Cl.Cl.Cl
分子式C12H28N4O•3HCl
分子量353.8
溶解度Water: 50 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N1-Acetylspermine is a monoacetylated derivative of spermine , an endogenous polyamine synthesized from spermidine , that displays lower Km and higher Vmax values than spermine, making it a better substrate of polyamine oxidase than the non-acetylated polyamine. [1] Spermine is required for eukaryotic cell growth and protein synthesis and is involved in the modulation of calcium-dependent immune processes. [2][3] N1-Acetylspermine has been used to study the uptake of the anticancer polyamine analog bleomycin-A5 by the human carnitine transporter SLC22A16.[4]

Reference:
[1]. Bolkenius, F.N., and Seiler, N. Acetylderivatives as intermediates in polyamine catabolism. International Journal of Biochemistry 13(3), 287-292 (1981).
[2]. Wallace, H.M., Fraser, A.V., and Hughes, A. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003).
[3]. Igarashi, K., and Kashiwagi, K. Polyamines: Mysterious modulators of cellular functions. Biochemical and Biophysical Research Communications 271(3), 559-564 (2000).
[4]. Aouida, M., Poulin, R., and Ramotar, D. The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5. The Journal of Biological Chemisty 285(9), 6275-6284 (2010).