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LXRβ agonist-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LXRβ agonist-2图片
CAS NO:1949801-52-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
LXRβ agonist-2 是一种高效 β 选择性肝 X 受体 (LXRβ) 激动剂,EC50为 7 nM,其选择性是 LXRα (EC50=200 nM) 的 28.5 倍,用于治疗动脉粥样硬化。
Cas No.1949801-52-8
Canonical SMILESOC(C(F)(F)F)(C(F)(F)F)C1=CC(CCC)=C(OC2=CC(O)=C(C(CN3C(NC(C)(C4=NC=C(OC(C)C)C=C4)C3=O)=O)=O)C=C2)C=C1
分子式C32H31F6N3O7
分子量683.59
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis[1]. EC50: 7 nM (LXRβ), 200 nM (LXRα)[1]

[1]. Koura M,et al. Discovery of a 2-hydroxyacetophenone derivative as an outstanding linker to enhance potency and β-selectivity of liver X receptor agonist. Bioorg Med Chem. 2016 Aug 15;24(16):3436-46.