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Tauro-β-muricholic Acid(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tauro-β-muricholic Acid(sodium salt)图片
CAS NO:145022-92-0
包装与价格：
包装价格(元)
500μg电议
1mg电议
5mg电议

产品介绍
Tauro-β-muricholic Acid sodium (T-βMCA sodium) 是一种内源性代谢物，是一种竞争性和可逆的法尼醇 X 受体 (FXR) 拮抗剂，IC50 为 40 μM.
Cas No.145022-92-0
别名牛磺-Α-鼠胆酸,Tauro-β-muricholate； TβMCA
化学名2-[[(3α,5β,6β,7β)-3,6,7-trihydroxy-24-oxocholan-24-yl]amino]-ethanesulfonic acid, monosodium salt
Canonical SMILESC[C@H](CCC(NCCS([O-])(=O)=O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@@H](O)[C@@H](O)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C.[Na+]
分子式C26H44NO7S o Na
分子量537.7
溶解度1mg/ml in ethanol, 10mg/ml in DMSO & DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

Tauro-β-muricholic acid (TβMCA) is a competitive and reversible antagonist of the farnesoid X receptor (FXR; IC50 = 40 μM) and a taurine-conjugated form of the murine-specific primary bile acid β-muricholic acid.[1] TβMCA accumulates in germ-free mice under normal conditions but is reduced after colonization with feces from a human donor.[1],[2] TβMCA is increased in the intestines of mice resistant to high-fat diet-induced obesity, fatty liver, and diabetes.[3]

Reference:
1. Sayin, S.I., Wahlstrom, A., Felin, J., et al. Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist. Cell Metab. 17(2), 225-235 (2013).
2. Wahlstrom, A., Kovatcheva-Datchary, P., Stahlman, M., et al. Induction of farnesoid X receptor signaling in germ-free mice colonized with a human microbiota. J. Lipid. Res. 58(2), 412-419 (2017).
3. Qi, Y., Jiang, C., Cheng, J., et al. Bile acid signaling in lipid metabolism: Metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys. Acta. 1851(1), 19-29 (2015).