生物活性
ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。
靶点信息
化学数据
| 目录号 | A15815 |
| 作用机制 | Inhibitor (抑制剂), Activator (激活剂) |
| M. Wt | 344.49 |
| Formula | C19H36O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 738606-46-7 |
| Synonyms | ESP-55016, ETC1002, ETC 1002 |
| SMILES | CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O |
溶解度
| In vitro | DMSO | 61 mg/mL (177.07 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 29.03 mL | 145.14 mL | 290.28 mL |
| 0.5 mM | 5.81 mL | 29.03 mL | 58.06 mL |
| 1 mM | 2.9 mL | 14.51 mL | 29.03 mL |
| 5 mM | 0.58 mL | 2.9 mL | 5.81 mL |
*The above data is based on the productmolecular weight 344.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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