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[D-Trp8]-γ-MSH(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
[D-Trp8]-γ-MSH(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
An MC3R agonist
Canonical SMILESO=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(NCC(O)=O)=O)CC1=CC=CC=C1)=O)=O)[C@H](NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@@H](NC(CNC([C@H](CCSC)NC([C@H](C(C)C)NC([C@@H](N)CC2=CC=C(O)C=C2)=O)=O)=O)=O)CC3=CN=CN3)=O)CC4=CC=CC=C4)=O)=O)CC5=CNC6=CC=CC=C56.OC(C(F)(F)F)=O
分子式C74H99N21O16S • XCF3COOH
分子量1570.8
溶解度Water: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

[D-Trp8]-γ-MSH is a melanocortin receptor 3 (MC3R) agonist and an analog of γ-melanocyte-stimulating hormone (γ-MSH).1It selectively induces cAMP accumulation in cells expressing MC3R over cells expressing MC4R or MC5R (EC50s = 0.33, 100, and 82 nM, respectively, for the human receptors).In vivo, [D-Trp8]-γ-MSH (162 nmol/kg, i.v.) reduces the incidence of ventricular tachycardia, ventricular fibrillation, and death in a rat model of myocardial ischemia-reperfusion injury.2It also inhibits urate-induced chemokine (C-X-C) motif ligand 1 (CXCL1) release and peritoneal polymorphonuclear leukocyte accumulation in recessive yellow (e/e) mice with a non-functional MC1R.3

1.Grieco, P., Balse, P.M., Weinberg, D., et al.D-Amino acid scan of γ-melanocyte-stimulating hormone: Importance of Trp8 on human MC3 receptor selectivityJ. Med. Chem.43(26)4998-5002(2000) 2.Mioni, C., Giuliani, D., Cainazzo, M.M., et al.Further evidence that melanocortins prevent myocardial reperfusion injury by activating melanocortin MC3 receptorsEur. J. Pharmacol.477(3)227-234(2003) 3.Getting, S.J., Lam, C.W., Leoni, G., et al.[D-Trp8]-γ-melanocyte-stimulating hormone exhibits anti-inflammatory efficacy in mice bearing a nonfunctional MC1R (recessive yellow e/e mouse)Mol. Pharmacol.70(6)1850-1855(2006)