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(S)-Amisulpride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(S)-Amisulpride图片
CAS NO:71675-92-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
(S)-Amisulpride (Esamisulpride) 是一种有效的多巴胺 D2/D3 受体拮抗剂。(S)-Amisulpride 是 5-HT7 受体的拮抗剂，KI 值为 900 nM。(S)-Amisulpride 具有抗精神和抗抑郁作用。
Cas No.71675-92-8
别名(S)-氨磺必利; Esamisulpride; SEP-4199
分子式C17H27N3O4S
分子量369.48
溶解度DMSO : 100 mg/mL (270.65 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(S)-Amisulpride (Esamisulpride) is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects[1][2].

(S)-Amisulpride (Esamisulpride) displays high affinity binding at both D2 and D3 receptors and is approximately twice as potent as racamisulpride and 20-50 times more potent than (R)-amisulpride at these receptors[2]

The (S)-amisulpride (10mg/kg, s.c.) stimulus is rapidly acquired and was shown to be dose-related, time dependent (effective between 30 and 120min) and stereoselective male C57BL/6 mice[1].

[1]. Timothy J Donahue, et al. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22.
[2]. Vincent Grattan, et al. Antipsychotic Benzamides Amisulpride and LB-102 Display Polypharmacy as Racemates, S Enantiomers Engage Receptors D2 and D3, while R Enantiomers Engage 5-HT7. ACS Omega. 2019 Aug 15;4(9):14151-14154.