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Dopamine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dopamine图片
CAS NO:51-61-6
包装与价格：
包装价格(元)
100mg电议
500mg电议

产品介绍
Dopamine 是在脑黑质，脑腹侧被盖区和下丘脑中产生的一种儿茶酚胺类神经递质，在大脑和身体中起着重要作用。Dopamine 通过 D2 多巴胺受体 (D2 dopamine receptor) 来诱导 VEGFR2 的内吞作用，这对于促进血管生成是至关重要的。
Cas No.51-61-6
别名2-(3,4-二羟基苯基)乙胺,ASL279 free base
分子式C8H11NO2
分子量153.18
储存条件Store at RT,protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dopamine is a catecholamine neurotransmitter that is produced in the substantia nigra, ventral tegmental area, and hypothalamus of the brain. Dopamine plays several important roles in the brain and body[1]. Dopamine acts through D2 dopamine receptors to induce endocytosis of VEGFR2, which is critical for promoting angiogenesis[1].

Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µM; 24hours)[2].

Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF[2].

[1]. JuÁrez OlguÍn H, et al. The Role of Dopamine and Its Dysfunction as a Consequence of Oxidative Stress. Oxid Med Cell Longev. 2016;2016:9730467.
[2]. Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.