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L-3-n-Butylphthalide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-3-n-Butylphthalide图片
CAS NO:3413-15-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
A phthalide with antiplatelet and neuroprotective activities
Cas No.3413-15-8
Canonical SMILESCCCC[C@H]1C2=CC=CC=C2C(O1)=O
分子式C12H14O2
分子量190.2
溶解度DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-3-n-Butylphthalide is a phthalide that has been found inA. graveolensand has antiplatelet and neuroprotective activities.1It inhibits ADP-, collagen-, and arachidonic acid-induced platelet aggregationex vivowhen administered at doses ranging from 3 to 100 mg/kg and inhibits thrombus formation in a collagen and epinephrine-induced rat model of experimental thrombosis. L-3-n-Butylphthalide (10 and 30 mg/kg per day) reduces amyloid-β-induced decreases in glutathione peroxidase (GPX) activity and decreases malondialdehyde (MDA) levels in the cortex and hippocampus and improves spatial learning and memory in the Morris water maze in a rat model of Alzheimer’s disease induced by intracerebroventricular infusion of amyloid-β (1-40) .2

1.Peng, Y., Zeng, X., Feng, Y., et al.Antiplatelet and antithrombotic activity of L-3-n-butylphthalide in ratsJ. Cardiovasc. Pharmacol.43(6)876-881(2004) 2.Peng, Y., Xing, C., Xu, S., et al.L-3-n-butylphthalide improves cognitive impairment induced by intracerebroventricular infusion of amyloid-beta peptide in ratsEur. J. Pharmacol.621(1-3)38-45(2009)