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Lanicemine dihydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Lanicemine dihydrochloride图片
CAS NO:153322-06-6
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Lanicemine (AZD6765) dihydrochloride 是一种低捕获的 NMDA 受体拮抗剂，Ki 为 0.56-2.1 µM。CHO 和爪蟾卵母细胞中，IC50 分别为 4-7 µM 和 6.4 µM。具有抗抑郁作用。
Cas No.153322-06-6
别名拉尼西明二盐酸盐; AZD6765 dihydrochloride; ARL 15896AR
Canonical SMILESN[C@H](C1=CC=CC=C1)CC2=CC=CC=N2.Cl.Cl
分子式C13H16Cl2N2
分子量271.19
溶解度DMSO : 240 mg/mL (884.99 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lanicemine (AZD6765) dihydrochloride is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 µM for NMDA receptor; IC50s of 4-7 µM and 6.4 µM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1].

References:
[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.