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(Rac)-Lanicemine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(Rac)-Lanicemine图片
CAS NO:61890-25-3
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
50mg电议

产品介绍
(Rac)-Lanicemine((Rac)-AZD6765)是Lanicemine的外消旋体。Lanicemine(AZD6765)是一种低捕获的NMDA受体拮抗剂,Ki为0.56-2.1 μM。CHO和爪蟾卵母细胞中,IC50分别为4-7μM和6.4μM。具有抗抑郁作用。
Cas No.61890-25-3
别名(Rac)-拉尼西明; (Rac)-AZD6765
Canonical SMILESNC(C1=CC=CC=C1)CC2=NC=CC=C2
分子式C13H14N2
分子量198.26
溶解度DMSO: 100 mg/mL (504.39 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(Rac)-Lanicemine ((Rac)-AZD6765) is the racemate of Lanicemine. Lanicemine (AZD6765) is a low-trapping NMDA channel blocker (Ki of 0.56-2.1 μM for NMDA receptor; IC50s of 4-7 μM and 6.4 μM in CHO and Xenopus oocyte cells, respectively). Antidepressant effects[1].

Lanicemine produces sustained antidepressant efficacy with minimal psychotomimetic adverse effects[1].Lanicemine (3, 10 or 30 mg/kg; intraperitoneal) not only engages brain circuits involved in the generation of gamma- electroencephalography (EEG), but also influences these networks independent of the broader systems-level disruptions typical of ketamine[1]. Animal Model: Male Sprague-Dawley rats[1]

[1]. Sanacora G, et al. Lanicemine: a low-trapping NMDA channel blocker produces sustained antidepressant efficacywith minimal psychotomimetic adverse effects. Mol Psychiatry. 2014 Sep;19(9):978-85.